100APPENDIX Cproposal for a total of $3 million to the Trust to subsidize the animal facility and for seed grants to enable junior scientists to pursue projects that have promise of opening new, major opportunities for which external grant support can then be expected from NIH. This is a concept similar to the Markey Research Program Grants at Caltech, University of California, San Francisco, and Washington University. Jeremy Knowles was the principal investigator for the Markey award. Impact of Markey Funds The Trust awarded Harvard $1.6 million in 1994. Half of the award ($800,000) was obligated to the Department for two purposes. The first was to help launch a Center for Imaging in Molecular and Cellular Biology, particularly through support for the purchase of a confocal microscope and related hardware. The Center offers access to the confocal microscope and an array of accessory hardware for high quality imaging and computer workstations for image analysis, modeling, and prepublication work. In 1998, the Department decided to use Markey funding to upgrade the Center computer and printing capabilities. Finally, part of the grant was also used as a partial funding to purchase a luminescence deconvolution microscope to be housed in the Center for Imaging. This powerful instrument operates using faint signals or live samples and provides three dimensional enhanced images. Through the Markey Faculty Exploratory Research Program, 15 awards of $32 thousand each were made between 1995 and 1997. These awards supported exploratory research and involved collaboration across disciplines. The second half of the award was used to support the animal facility of the Faculty of Arts and Sciences, which was critical to the research in vertebrate development conducted by Andrew McMahon and Elizabeth Robertson. Their research required significant numbers of mice. OREGON HEALTH SCIENCES UNIVERSITY VOLLUM INSTITUTE FOR ADVANCED BIOMEDICAL RESEARCH MAY 2002 History and Background of Markey Funding The Vollum Institute of the Oregon Health Sciences University was made possible by a gift of $23 million from Mr. and Mrs. Howard Vollum. In addition, a $20 million grant from the federal government was an important component of the basic funding for the Institute.
